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KMID : 0603820120180030291
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Journal of Experimental & Biomedical Science
2012 Volume.18 No. 3 p.291 ~ p.298
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Antiobesity Effect of Mixture of Black Garlic and Garsinia cambogia Extracts in 3T3-L1 Adipocytes and L6 Skeletal Muscle Cells
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Jung Young-Mi
Lee Dong-Sub
Lee Seon-Ha
Jeoung Nam-Ho
Kim Bok-Jo
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Abstract
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he antiobesity effect of the mixture of black garlic and Garsinia cambogia extracts (BGG) was investigated by measuring the Oil red O staining and the expressions of adipogenic genes during preadipocyte differentiation by real-time PCR in the 3T3-L1 adipocytes. BGG reduced contents of Oil red O dye in the 3T3-L1 adipocytes. mRNA expression levels of SREBP1c, C/EBPa, aP2/FABP4, and PPARγ which are adipogenic transcription factor, in cells treated with BGG were also significantly down regulated. Also, the phosphorylation of AMP-activated protein kinase (AMPK) in L6 cells was more increased by BGG. These results indicate that BGG seems to be more attractive compound for application of industry than individual extracts such as black garlic and Garsinia cambogia, considering it has two effects not only inhibit the preadipocyte differentiation but also activate the phosphorylation of AMPK unlike other two compound.
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KEYWORD
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BGG, Antiobesity effect, Adipocyte differentiation, AMP-activated protein kinase
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